Creative Biolabs

Mouse Anti-Human α-Synuclein 117-122 Monoclonal Antibody (Clone A15126D), Unconjugated

[CAT#: NAB201251LS]

Anti-α-Synuclein 117-122 Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; IHC-P; ELISA

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Description
α-synuclein is expressed principally in the nervous system. At least three isoforms of α-synuclein are produced through alternative splicing. The most common isoform is a 140 amino acid-long transcript. Other isoforms includes, a-synuclein-126, lacking residues 41-54; and α-synuclein-112, which lacks residues 103-130. α-synuclein's physiological role is poorly understood, but the protein has been implicated in regulating dopamine release and transport, synaptic vesicle clustering, and functioning as a SNARE-complex chaperone. α-synuclein fibrils are a major component of the intracellular Lewy bodies that are associated with Parkinson's disease, Lewy body dementia, and multiple system atrophy. α-synuclein is phosphorylated at low levels under normal physiological conditions whereas the majority of the protein is phosphorylated in Lewy bodies at S129.
Immunogen
KLH-conjugated peptide
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b, κ
Clone Number
A15126D
Applications
WB; IHC-P; ELISA
Application Notes
WB (0.5-2.0 µg/mL); IHC-P (2.0-10 µg/mL); ELISA (20 ng/mL-3.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Alpha Synuclein
Official Name
SNCA
Full Name
Alpha-synuclein
Alternative Names
SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha
Gene ID
6622 (Human); 20617 (Mouse)
Uniprot ID
P37840 (Human); P37840 (Mouse)
1. Mor DE, et al. 2016. Neurobiol. Dis. 88:66.
2. Jucker M, Walker LC. 2013. Nature. 501:45.
3. Bartels T, et al. 2011. Nature. 477(7362):107.
4. Devine MJ, et al. 2011. Mov. Disord. 26:2160.
Biomaterials
Neural Antibodies
Neural Proteins & Peptides
Neural Genes
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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