Creative Biolabs

Mouse Anti-NFkB p50 Monoclonal Antibody (AB004), Unconjugated

[CAT#: NAB2007FY964]

Mouse Monoclonal [AB004] to NFkB p50

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB

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Description
Mouse anti-human NFkB p50 antibody recognizes nuclear factor NF-kappa-B p50 subunit, also known as DNA binding factor KBF1, NF-kappabeta, nuclear factor NF-kappa-B p50 subunit or nuclear factor κ-B DNA binding subunit. NFKB1 encodes a 105 kD protein, which can be co-translationally processed by 26S proteasome to produce a 50 kD protein. 105 kD protein is a specific transcription inhibitor of Rel protein, and 50 kD protein is the DNA binding subunit of the NF-κB (NFKB) protein complex. NFKB is a transcriptional regulator that can be activated by various intracellular and extracellular stimuli, such as cytokines, free radicals, ultraviolet radiation, and bacterial or viral products. The activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a variety of biological functions. Inappropriate activation of NFKB is associated with many inflammatory diseases, and continuous inhibition of NFKB can lead to inappropriate immune cell development or cell growth delay. For NFKB1, two transcript variants encoding different isoforms were found.
Immunogen
Recombinant human NFkB p50 (aa 1-200).
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
AB004
Applications
WB
Application Notes
WB: 1/1000
Relevant Diseases
Alzheimer's Disease; Neurodegenerative Disease
Research Areas
Neuroregeneration
Conjugation
Unconjugated
Form
Liquid
Formulation
PBS, 1% BSA, 0.09% Sodium Azide
Preservatives
YES
Purification
Protein G
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
NFKB1
Official Name
NFKB1
Full Name
Nuclear Factor Kappa B Subunit 1
Alternative Names
Nuclear Factor Kappa B Subunit 1; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; DNA-Binding Factor KBF1; EBP-1; Nuclear Factor Kappa-B DNA Binding Subunit; Nuclear Factor NF-Kappa-B P105 Subunit; Nuclear Factor NF-Kappa-B P50 Subunit; NF-Kappabeta; NF-Kappa-B; NF-KappaB;
Gene ID
4790(Human); 18033(Mouse); 81736(Rat)
Uniprot ID
P19838(Human); P25799(Mouse); Q63369(Rat)
For Research Use Only. Not For Clinical Use.
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