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Creative Biolabs
Product

Mouse Anti-PABPN1 Monoclonal Antibody (CBP2850)

[CAT#: NAB20101927CR]

Mouse Monoclonal (3C12E12) to PABPN1

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
IHC; WB; ELISA

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Product Overview

Description

Poly(A) Binding Protein Nuclear 1(PABPN1) is one of the isoforms of poly(A) binding protein (PABP) that locating to the nucleus in eukaryotic cells. And PABPN1 plays important role in mRNA stability by regulating of poly-A tail length, mRNA decay and proximal polyadenylation site (PAS) utilization at the 3'-UTR (PMID:23300856). Another report showed that PABPN1 shuttles between the nucleus and the cytoplasm to export poly(A) RNA from the nucleus (PMID:23601051). It is reported that PABPN1 is ubiquitously expressed in almost all tissues, however, mutations in PABPN1 causes Oculopharyngeal Muscular Dystrophy (OPMD) which affected in skeletal muscles specifically.

Expression Host

Mammalian cells

Immunogen

PABPN1 fusion protein Ag27470

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2850

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neuroendocrinology

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

PABPN1

Official Name

PABPN1

Full Name

Poly(A) binding protein, nuclear 1

Alternative Names

OPMD; PAB2; PABII; PABP 2; PABP2; PABPN1; Poly(A) binding protein 2; Poly(A) binding protein II

Gene ID

8106(Human); 54196(Mouse); 116697(Rat)

Uniprot ID

Q86U42(Human); Q8CCS6(Mouse)
References

1. Wheeler, J. M., McMillan, P., Strovas, T. J., Liachko, N. F., Amlie-Wolf, A., Kow, R. L.,... & Saxton, A. (2019). Activity of the poly (A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science Translational Medicine, 11(523).
Publications

Publications (0)

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