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Creative Biolabs
Product

NeuroMab™ Mouse Anti-Parkin Monoclonal Antibody (CBP1953)

[CAT#: NAB2007FY447]

Mouse Monoclonal [1H4] to Parkin

Host Species:
Mouse
Species Reactivity:
Human
Applications:
IF; WB

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Product Overview

Description

Mouse anti-human Parkin antibody, clone 1H4 recognizes the human E3 ubiquitin protein ligase Parkin, also known as Parkin or Parkinson Juvenile Disease Protein 2. Parkin is the 465 amino acid ~ 50 kDa enzyme component of the polyprotein E3 ubiquitin ligase complex.
Noted that mutations in the PARK2 gene affect the susceptibility to Parkinson's disease (PARK) and Parkinson's disease 2 (also known as autosomal recessive juvenile Parkinson's disease (PARK2)), which is similar to classic Parkinson's disease. The difference lies in the early DOPA-induced dyskinesia, symptoms, sleep improvement, dystonia and hyperreflexia.

Immunogen

Recombinant protein corresponding to amino acids 288-388 of human PARK2

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG3

Clone Number

CBP1953

Applications

IF; WB

Application Notes

IF (0.1 ug/ml-10 ug/ml); WB (0.5 ug/ml-4 ug/ml)

Relevant Diseases

Parkinson's Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1580
Product Properties

Form

Liquid

Formulation

PBS; None present

Preservatives

None present

Concentration

0.5 mg/ml

Purification

Affinity chromatography on Protein A.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

Parkin

Official Name

PARK2

Full Name

Parkin

Alternative Names

PRKN; parkin RBR E3 ubiquitin protein ligase; AR-JP; LPRS2; PDJ; PARK2

Gene ID

5071(Human); 50873(Mouse); 56816(Rat)

Uniprot ID

O60260(Human); Q9WVS6(Mouse); Q9JK66(Rat)
References

1. Brody, K. M. et al (2008) Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain.
2. Scuderi, S. et al. (2014) Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain.
Publications

Publications (0)

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