Creative Biolabs

Mouse MBP C1 Isoform [C-6His]

[CAT#: NPP-2106-S07]

Mouse MBP Peptide with C-6His Tag

Species:
Mouse
Sequence:
ASQKRPSQRS KYLATASTMD HARHGFLPRH RDTGILDSIG RFFSGDRGAP KRGSGKDSHT RTTHYGSLPQ KSQHGRTQDE NPVVHFFKNI VTPRTPPPSQ GKGRGLSLSR FSWGAEGQKP GFGYGGRASD YKSAHKGFKG AYDAQGTLSK IFKLGGRDSR SGSPMARRLE HHHHHH
Tag:
C-6xHis

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Description
The intrinsically disordered, 18.5-kDa isoform of Myelin Basic Protein (MBP) is a peripheral membrane protein that is essential to proper myelin formation in the central nervous system. Unmodified MBP (C1 charge variant, the most abundant variant of the healthy human adult myelin) is an extremely positively charged protein (+19 at neutral pH). MBP acts in oligodendrocytes both to adjoin membrane leaflets to each other in forming compact myelin sheath and as a hub in numerous protein-protein and protein-membrane interaction networks. Interaction of MBP with its various partners may be mediated, in part, by post-translation modifications (PTMs) such as phosphorylation and deimination that result in charge reduction and are developmentally regulated. Distinct patterns of post-translational modifications, most notably excessive deimination, also occur in multiple sclerosis, leading to speculation that these aberrant PTMs are a part of the disease pathogenesis.
Species
Mouse
Expression Host
E. coli
Sequence
ASQKRPSQRS KYLATASTMD HARHGFLPRH RDTGILDSIG RFFSGDRGAP KRGSGKDSHT RTTHYGSLPQ KSQHGRTQDE NPVVHFFKNI VTPRTPPPSQ GKGRGLSLSR FSWGAEGQKP GFGYGGRASD YKSAHKGFKG AYDAQGTLSK IFKLGGRDSR SGSPMARRLE HHHHHH
Molecule Mass
19421.5 Da
Tag
C-6xHis
Form
Liquid
Formulation
10mM KPB pH 7.4
Purity
>90 %, purified by IMAC followed by ion-exchange chromatography
Storage
Store at -20°C
Research Use Only
Research Use Only
Target
Myelin Basic Protein
Official Name
MBP
Full Name
Myelin basic protein
Alternative Names
PROM1
Gene ID
4155(Human); 17196(Mouse); 24547(Rat)
Neural Genes
Neural Antibodies
Neural Proteins & Peptides
For Research Use Only. Not For Clinical Use.
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