Creative Biolabs

Mouse Myelin Basic Protein Antibody

[CAT#: NAB-2102-MP250]

Host Species:
Mouse
Species Reactivity:
Human; Mouse; Rat
Applications:
WB; IF

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Description
Myelin basic protein is 30 kinds of myelin proteins found in the central nervous system. Can induce experimental allergic encephalomyelitis (EAE), a t-lymphocyte-mediated delayed hypersensitivity disease; although each animal seems to respond to different fragments of 170 amino acid peptides. Four different subtypes were identified by cDNA cloning. Except for the insertion or deletion of the two peptide fragments encoded by exons 2 and 5, these four variants are all the same. Myelin basic protein is expressed in the white matter myelin of oligodendrocytes, brain, spinal cord and peripheral nerves, but less expressed in gray matter.
MBP plays an important role in forming and stabilizing this compact multi-layer double-layer structure. In vitro, MBP is suitable as a substrate for many protein kinases, including ERK and p38 MAP kinase that phosphorylate MBP at T98.
Immunogen
Mixture of 3 MBP peptides which are the different forms of the protein which are alternate transcription from a single gene.
Species Reactivity
Human; Mouse; Rat
Host Species
Mouse
Isotype
IgG
Applications
WB; IF
Application Notes
ICC 1:2000; IHC 1:2000; WB 1:10,000
Form
liquid
Purification
Affinity Purified
Shipping
Frozen (Polar Packs)
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Target
Myelin Basic Protein
Official Name
MBP
Full Name
myelin basic protein
Alternative Names
Myelin A1 protein; MBP; Myelin membrane encephalitogenic protein; Myelin basic protein
Gene ID
4155(Human);17196(Mouse)
Uniprot ID
P02686(Human);P04370(Mouse)
Neural Antibodies
Neural Proteins & Peptides
Neural Genes
For Research Use Only. Not For Clinical Use.
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