Neurodegenerative Disease Modeling

Neurodegenerative disease describes a class of diseases characterized by the progressive dysfunction and loss of neurons, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Every year, neurodegenerative diseases take a steep toll on millions of people, affecting individuals, their caregivers, families, and communities. Most neurodegenerative diseases share a common course: uncontrolled neuronal death that leads to progressive decline in brain functions, such as cognition or locomotor control. Neurodegenerative diseases progress mercilessly, robbing their victims first of their minds, then of control over basic bodily functions, and finally of their life; the diseases are always fatal. The unclear pathogenesis has led more and more neuroscientists to study neurodegeneration.

Our Neurodegenerative Disease Models

The pathological study of this type of disease has been a problem due to the complexity of brain function, the models provided by Creative Biolabs can simulate human-related neurodegenerative diseases which provide an important basic platform for the study of the pathogenesis and drug screening.

Neurodegenerative Disease Cell Models

In recent years, the development of in vitro cellular models to simulate the pathogenesis of neurodegenerative diseases has become a concern for neuroscientists. Multiple cell models can be established and used to study neurodegenerative diseases at the micro level according to different research purposes. At Creative Biolabs, we have a mature cell model building platform, which can complete the establishment of various transgenic cell lines, the isolation and extraction of primary cells, and the differentiation of patient-specific iPS cells to support your research on neurodegenerative diseases.

Neurodegenerative Disease Brain Slice Models

Organotypic brain slice cultures have proven to be very useful in investigating cellular and molecular processes of the brain in vitro, it is an important tool for obtaining insights into the pathogenesis of neurodegenerative diseases and a supplement to in vivo animal experiments. According to your project, Creative Biolabs provides you with brain slice culture and neurodegenerative disease modeling services, including downstream immunohistochemistry, parameter measurement, and data processing services. Please contact us for more technical support.

Over the last decade, we have successfully provided diverse custom in vitro models to clients worldwide including AD models, PD models, HD models, ALS models, epilepsy models, and fragile X syndrome disease models. If you are interested in our service, please contact us directly.

Neurodegenerative Disease Animal Models

At Creative Biolabs, we have a skilled genetically modified animal preparation platform, and we have provided multiple animal models for global partners in the last decade.

• Mouse model
The mice provided by Creative Biolabs have become the favorite mammalian models result of their genetic proximity to humans, the possibility of genes manipulating their genomes, and the availability of many tools, mutants, and inbred lines. At Creative Biolabs, you can customize your transgenic mouse model according to your project.

• Rhesus monkey model
Non-human primate models are more similar to human neurodegenerative diseases, especially in the early stages of the disease. Rhesus models from Creative Biolabs can provide a more objective and realistic basis for your study of neurodegenerative diseases.

• Zebrafish model
Zebrafish genes and their human homologs have conserved functions. Thus, this makes zebrafish an excellent animal model widely used in the in vivo screening of several neurodegenerative diseases. Zebrafish's advantages and characteristics make them an excellent tool for the development of new drugs against various neurodegenerative disorders.