Neurodegenerative Disease Modeling Services

Neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease, are characterized by the progressive degeneration of neurons, leading to cognitive impairment and motor dysfunction. Gaining insights into these intricate conditions is vital for creating successful treatment options and enhancing the quality of life for affected individuals. Disease modeling in neuroscience plays a pivotal role in this endeavor, enabling researchers to dissect the underlying mechanisms and identify potential therapeutic targets.

Creative Biolabs' in vitro modeling approaches utilize advanced iPSC technology and 3D architectures to closely mimic the brain environment. These models not only replicate the cellular and biochemical features of neurodegenerative diseases but also facilitate the evaluation of new drug candidates, ultimately aiding the fight against neurodegenerative diseases.

Fig.1 In vitro brain models for neurodegeneration research.¹

Our Neurodegenerative Disease Models

Our in vitro models for neurodegenerative diseases provide a reliable platform for understanding disease mechanisms, facilitating drug discovery, and ultimately advancing therapeutic strategies tailored to combat these complex neurological disorders.

2D Cell Models

• Primary cells

Primary cells provide a closer resemblance to the native environment of neurons, as they are directly isolated from tissues. This leads to more physiologically relevant responses and better modeling of disease progression, offering insights into disease mechanisms that are more applicable to human biology.

• Immortalized cell lines

Immortalized cell lines offer consistency and reproducibility, making them an ideal choice for high-throughput screening and mechanistic studies. These cells are easy to maintain and can be genetically modified, allowing for the exploration of specific genetic factors involved in neurodegenerative diseases.

• Human iPSC-derived cells

Human iPSC-derived cells are invaluable because they can be generated from patients, capturing disease-specific phenotypes and genetic backgrounds. This enables the modeling of neurodegenerative diseases with a personalized approach, facilitating the development of potential therapeutic interventions tailored to individual patients.

Precision Modeling of Neurological Disorders: A Guide to Cell Source Selection

3D Cerebral Organoids

• Unguided brain organoids

These organoids are derived from pluripotent stem cells and develop spontaneously, recapitulating key aspects of early brain development without external guidance.

• Regionalized organoids

By patterning stem cells, regionalized organoids can mimic specific brain regions, enabling the study of region-specific pathologies and functions in neurodegenerative conditions.

• Assembloids

Assembloids are sophisticated structures formed by integrating multiple organoids, allowing for the investigation of inter-regional interactions and their role in neurodegenerative disease mechanisms.

• Bioengineered organoids

These organoids are enhanced using biomaterials and external stimuli, providing a more controlled environment that can emulate complex in vivo conditions to study disease progression and potential therapies.

Microfluidics

• BBB-on-chip

BBB-on-chip provides a functional blood-brain barrier microenvironment that is essential for effective drug testing in neurodegenerative disease research.

• Neuroinflammation Models

The neuroinflammation models effectively simulate residual and peripheral inflammatory responses, allowing for a deeper understanding of neurodegenerative processes.

• Multi-Organ Chip Models

Multi-organ chip models replicate organ crosstalk, including vital gut-brain and lung-brain interactions, enhancing the study of complex neurodegenerative mechanisms.

Bioengineered Tissue Models

• Biomaterials

Bioengineered tissue models utilize advanced biomaterials that promote enhanced neurogenesis and neural differentiation, offer a variable choice of materials, and significantly reduce cell death while facilitating vascularization in brain models.

• Bioprinting

Employ bioprinting technology to achieve precise spatial control, enhancing the integration of multiple cell types and materials, which allows for high reproducibility and scalability in our neurodegenerative disease research.

Related Services

Reference

1. Yan, Yuwei, and Ann-Na Cho. "Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study." Int J Mol Sci. 2024;25(12):6522. Distributed under Open Access License CC BY 4.0 without modification.