NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P612)
[CAT#: NRP-0422-P612]
A functional antibody raised against Human Alpha Synuclein.
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- DB; ELISA; FC; IHC; In Vitro
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The antibody has a high affinity for aggregated forms of α-synuclein and a low affinity for monomeric forms of α-synuclein. The antibody is useful in the diagnosis of neurodegenerative diseases.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
DB; ELISA; FC; IHC; In Vitro
Relevant Diseases
Parkinson's Disease
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
>95% by SDS PAGE or HPLC
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Product Pictures
ELISA
Figure 1 shows the results of inhibition ELISA using this antibody.
Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.
DB
Figure 2 shows the Pepscan results of a dot blot epitope assay for the monoclonal antibodies Syn-F1, Syn-F2, Syn-O1, Syn-O2, Syn-O3 and Syn-O4, and the Syn-1 antibody as a control.
Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.
ELISA
Figure 3 shows the results of a sandwich ELISA for the detection of phosphorylated Ser129-α-synuclein aggregates.
Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.
IHC
Figure 4 shows the immunohistochemical analysis of Parkinson's disease tissue.
Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.
FuncS
Figure 5 shows the percentage of dot-positive cells for each antibody tested.
Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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