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Creative Biolabs

HOT NeuroMab™ Anti-Alpha Synuclein Antibody(NRP-0422-P614)

[CAT#: NRP-0422-P614] Review(5) Q&As(2)

A functional antibody raised against Human Alpha Synuclein.

Host Species:
Mouse
Species Reactivity:
Human
Applications:
DB; ELISA; FC; IHC; In Vitro

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Product Overview

Description

The antibody has a high affinity for aggregated forms of α-synuclein and a low affinity for monomeric forms of α-synuclein. The antibody is useful in the diagnosis of neurodegenerative diseases.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

DB; ELISA; FC; IHC; In Vitro

Relevant Diseases

Parkinson's Disease
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

AlphaSynuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha

Gene ID

6622 (Human); 20617 (Mouse)

Uniprot ID

Product Pictures
ELISA

Figure 1 shows the results of inhibition ELISA using this antibody.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

DB

Figure 2 shows the Pepscan results of a dot blot epitope assay for the monoclonal antibodies Syn-F1, Syn-F2, Syn-O1, Syn-O2, Syn-O3 and Syn-O4, and the Syn-1 antibody as a control.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

ELISA

Figure 3 shows the results of a sandwich ELISA for the detection of phosphorylated Ser129-α-synuclein aggregates.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

IHC

Figure 4 shows the immunohistochemical analysis of Parkinson's disease tissue.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

FuncS

Figure 5 shows the percentage of dot-positive cells for each antibody tested.

Rats were treated with intraocular injections of 3H4 Fab solution (2.4 pg/eye) compared to sham or vehicle controls. Statistical significance is shown.

Publications

Publications (0)

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Customer Reviews and Q&As
Customer Reviews Average Customer Ratings Overall
5.0
user
Excellent
As a postdoc working on synaptic proteins, I found the antibody to be highly reliable
It provides clear and distinct bands in Western blotting and excellent staining in immunofluorescence. The antibody has significantly improved our ability to detect alpha-synuclein in various samples.
user
Excellent
Gave us confidence in our findings
We use the antibody for detecting alpha-synuclein in both human and mouse samples. The cross-reactivity is minimal, and the results are consistent and reliable. This has been a valuable tool in our study of neurodegenerative disorders.
user
Excellent
Highly recommended for any neuroscience lab
In our quest to understand the pathology of Parkinson's disease, the antibody has been indispensable. The antibody's performance in immunofluorescence microscopy is particularly noteworthy, providing clear and detailed images of alpha-synuclein localization.
user
Excellent
It's a top-tier product for alpha-synuclein detection
We've been using the antibody for over a year now, and it's never disappointed. The antibody provides strong, clear bands in our Western blots and beautiful staining in our immunohistochemistry studies.
user
Excellent
A reliable reagent
We've been using the antibody for our studies on alpha-synuclein aggregation. The results have been consistently excellent, with clear detection of oligomers and fibrils in our assays. This antibody is a must-have for anyone researching synucleinopathies.
Q&As
Are there any recommended positive controls for this antibody?
We recommend using brain tissue from Parkinson's disease models or other neurodegenerative disease samples as positive controls when using the antibody. These samples typically have elevated levels of alpha-synuclein, providing robust positive signals for your immunodetection assays.
Does this antibody cross-react with beta or gamma-synuclein?
No, the antibody is highly specific to alpha-synuclein and does not significantly cross-react with beta or gamma-synuclein. This specificity is crucial for studies focusing on the role of alpha-synuclein without interference from other synuclein family members.
For Research Use Only. Not For Clinical Use.
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