NeuroMab™ Anti-Amyloid Beta BBB Shuttle Antibody, Clone mAb31
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- In Vitro
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 Binding properties of the fusion protein to the Aβ structure.
Figure 2 Plaque decoration of anti-Aβ monoclonal antibody mAb31.
Figure 3 shows the quantification of the dual Fab-mAb31 construct.
Figure 4 shows the quantification of individual Fab-mAb31 constructs.
Figure 5 Plaque decoration of two different doses of anti-Aβ monoclonal antibody mAb31 and a very low dose of single Fab mAb31 (single Fab fused to the C-terminus of mAb31)
Figure 6 Quantitative expression of TfR cells treated with single Fab-mab31 or double Fab-mAb31
Figure 7 In vivo cellular trafficking of TfR treated with single Fab-mab31 or double Fab-mAb31.
Figure 8 In vivo cellular trafficking of TfR treated with single Fab-mab31 or double Fab-mAb31.
Figure 9 Antibody multimers with TfR scFab fragments fused to the Fc C-terminus do not induce ADCC.
Figure 10 Quantitative morphological analysis of plaque immunohistochemical staining showing cortex and hippocampus.
Figure 11 demonstrates that a low dose of the sFab construct (2.66 mg/kg) reached plaques in the brain rapidly and significantly compared to mAb31 at 2 mg/kg and 10 mg/kg.
Figure 12 In vivo cellular trafficking of TfR treated with double Fab-mab31.
Figure 13 In vivo cellular trafficking of TfR treated with a single Fab-mab31.
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