NeuroMab™ Anti-Cavβ1 calcium channel BBB Shuttle Antibody, Clone N7/18

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNB1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 19-34 (PMEVFDPSPQGKYSKR) of human Cav1 (also known as Voltage-dependent L-type calcium channel subunit beta-1, Calcium channel voltagedependent subunit beta 1, Cacnb1, Cacnlb1 and CAB1, accession number Q02641)
Rat: 100% identity (16/16 amino acids identical)
Mouse: 100% identity (16/16 amino acids identical)
100% identity between all Cav1 splice variants
<50% identity with Cav2, Cav3 and Cav4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N7/18

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with Cavβ2, Cavβ3 or Cavβ4

Research Areas

Ca2+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CACNB1

Official Name

CACNB1

Full Name

Cavbeta1 Ca2+ channel

Alternative Names

CACNB1; Calcium channel; voltage-dependent; beta 1 subunit

Uniprot ID

Q02641

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N7/18 (left) or N52A/42 (right) TC supe.