NeuroMab™ Anti-Cav1.2 BBB Shuttle Antibody, Clone N263/31

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNA1C BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 808-874 (cytoplasmic loop between repeat II and III) of rat Cav1.2 (also known as Voltage-dependent L-type calcium channel subunit alpha-1C, CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, Brain class C and MELC-CC, accession number P22002)
Mouse: 100% identity (67/67 amino acids identical)
Human: 86% identity (58/67 amino acids identical)
<<50% identity with other Cav1 channels

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N263/31

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Cav1.3

Research Areas

Ca2+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CACNA1C

Official Name

CACNA1C

Full Name

Cav1.2 Ca2+ channel

Alternative Names

Calcium Voltage-Gated Channel Subunit Alpha1 C; Calcium Channel; L Type; Alpha-1 Polypeptide; Isoform 1; Cardiac Muscle; Calcium Channel; Voltage-Dependent; L Type; Alpha 1C Subunit; CACNL1A1; CCHL1A1; CACH2; CACN2; Voltage-Gated L-Type Calcium Channel Cav1.2 Alpha 1 Subunit; Splice Variant 10*; Calcium Channel; Cardic Dihydropyridine-Sensitive; Alpha-1 Subunit;

Uniprot ID

P22002

Product Pictures

Fig. 1 Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with untagged Cav1.2, Cav1.3 or Kv2.1 plasmids and probed with N263/31 (left) and L57/46 (right) TC supe.

Publications