Product
NeuroMab™ Anti-Cav1.3 calcium channel BBB Shuttle Antibody, Clone L48A/9
[CAT#: NRZP-0423-ZP62]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CaV1.3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Synthetic peptide amino acids 859-875 (DNKVTIDDYQEEAEDKD, cytoplasmic loop between repeat II and III) of rat Cav1.3 (also known as voltage-dependent Ltype calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732)
Mouse: 94% identity (16/17 amino acids identical)
Human: 88% identity (15/17 amino acids identical)
Mouse: 94% identity (16/17 amino acids identical)
Human: 88% identity (15/17 amino acids identical)
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
L48A/9
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Cav1.2
Research Areas
Ca2+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
CaV1.3
Official Name
CACNA1D
Full Name
Cav1.3 Ca2+ channel
Alternative Names
CACNA1D; CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3; PASNA; SANDD; calcium voltage-gated channel subunit alpha1 D
Uniprot ID
P27732
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
IHC
Fig. 2 Adult rat hippocampus immunohistochemistry.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
