NeuroMab™ Anti-Cav3.1 Ca2+ channel BBB Shuttle Antibody, Clone N178A/9

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNA1G BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 2052-2172 (cytoplasmic C-terminus) of mouse Cav3.1 (also known as Voltage-gated/dependent T-type calcium channel alpha-1-G subunit, Cacna1g and NBR13, accession number Q9WUT2)
Rat: 96% identity (117/121 amino acids identical)
Human: 80% identity (98/122 amino acids identical)
<30% identity with Cav3.2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N178A/9

Applications

WB; IHC; ICC

Research Areas

Ca2+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CACNA1G

Official Name

CACNA1G

Full Name

Cav3.1 Ca2+ channel

Alternative Names

CACNA1G; Calcium channel; voltage-dependent; T type; alpha 1G subunit

Uniprot ID

Q9WUT2

Product Pictures

Fig. 1 Immunoblot of crude brain membranes from adult rat (RBM) and Cav3.1 wild-type (WT) and knockout (KO) mice and probed with N178A/9 (left) and K89/34 (right).