NeuroMab™ Anti-Cav3.2 calcium channel BBB Shuttle Antibody, Clone N55/10

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CACNA1H BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1019-1293 (cytoplasmic loop between repeat II and repeat III) of human Cav3.2 (also known as Voltage-dependent T-type calcium channel subunit alpha-1H, Lowvoltage-activated calcium channel alpha1 3.2 subunit, CACNA1H and Kiaa1120, accession number O95180), epitope mapped to amino acids 1179-1192 (AEDGRAAPGPRATP)
Rat: 77% identity (224/279 amino acids identical), 54% identity for epitope (12/22 amino acids identical), 89% identity for highlighted epitope sequence (8/9 amino acids identical)
Mouse: 77% identity (224/279 amino acids identical), 54% identity for epitope (12/22 amino acids identical), 89% identity for highlighted epitope sequence (8/9 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N55/10

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with Cav3.1

Research Areas

Ca2+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CACNA1H

Official Name

CACNA1H

Full Name

Cav3.2 Ca2+ channel

Alternative Names

Calcium Voltage-Gated Channel Subunit Alpha1 H; Calcium Channel; Voltage-Dependent; T Type; Alpha 1H Subunit; Low-Voltage-Activated Calcium Channel Alpha1 3.2 Subunit; Voltage-Gated Calcium Channel Subunit Alpha Cav3.2; Calcium Channel; Voltage-Dependent; T Type; Alpha 1Hb Subunit; Voltage Dependent T-Type Calcium Channel Alpha-1H Subunit; Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H; Low-Voltage-Activated Calcium Channel Alpha13.2 Subunit;

Uniprot ID

O95180

Product Pictures

Fig. 1 Stable cell immunoblot: extracts of HEK cells stably-expressing Flag-tagged Cav3.2, Cav3.1 or untagged Kv2.1 plasmid and probed with N55/10 TC supe (left) or Rabbit anti-Flag (right).