NeuroMab™ Anti-CLN3 BBB Shuttle Antibody, Clone N380/87

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CLN3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-37, 59-98, 149-179, 233-277, 299-357 and 379-406 (non-helical domains) of human CLN3 (also known as Ceroid lipofuscinosis, neuronal 3, Battenin, Batten disease protein, BTS and rCG_40703, accession number Q13286)
Mouse: 83% identity overall (198/240 amino acids identical)
Rat: 81% identity overall (194/240 amino acids identical)
<50% identity with other CLN proteins

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N380/87

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with other CLN proteins

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CLN3

Official Name

CLN3

Full Name

CLN3

Alternative Names

CLN3; BTS; JNCL; ceroid-lipofuscinosis; neuronal 3; battenin; BTN1; CLN3 lysosomal/endosomal transmembrane protein; battenin

Uniprot ID

Q13286

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with untagged CLN3, Myc-tagged CLN6, Myctagged CLN8 or untagged Kv2.1 plasmid probed with N380/87 (left) or 19E10 (right) TC supe.

Publications