NeuroMab™ Anti-CLN6 BBB Shuttle Antibody, Clone N400/24

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CLN6 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 2-55, 131-177 and 281-311 (non-helical domains) of human CLN6 (also known as Ceroid-lipofuscinosis neuronal protein 6, accession number Q9NWW5)
Mouse: 73%, 100% and 94% identity (39/53, 47/47 and 29/31 amino acids identical)
Rat: 67%, 100% and 90% identity (36/53, 47/47 and 28/31 amino acids identical)
<50% identity with other CLN proteins

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N400/24

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with other CLN proteins

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CLN6

Official Name

CLN6

Full Name

CLN6

Alternative Names

CLN6; CLN4A; HsT18960; nclf; ceroid-lipofuscinosis; neuronal 6; late infantile; variant; transmembrane ER protein; CLN6 transmembrane ER protein

Uniprot ID

Q9NWW5

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with Myc-tagged CLN6, Myc-tagged CLN8 or untagged Kv2.1 plasmid probed with N400/24 (left) or 19E10 (right) TC supe.

Publications