NeuroMab™ Anti-FGFR1 BBB Shuttle Antibody(NRZP-1022-ZP3893)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

WB; ELISA; In Vitro; In Vivo; Agonist

Relevant Diseases

Multiple Sclerosis; Glioma

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

FGFR1

Official Name

FGFR1

Full Name

Fibroblast Growth Factor Receptor 1

Alternative Names

Fibroblast Growth Factor Receptor 1; Basic Fibroblast Growth Factor Receptor 1; Fms-Related Tyrosine Kinase 2; Proto-Oncogene C-Fgr; EC 2.7.10.1; BFGF-R-1; FGFR-1; N-SAM; BFGFR; FGFBR; FLT-2; HBGFR; FLT2; CEK; FLG;

Product Pictures

Figure 1 shows the GAL-Elk1 luciferase assay in rat L6 cells. Cells were co-transfected with expression vectors for the indicated FGFR isoforms together with GAL-Elk1, SV40-Renilla luciferase and Gal-responsive firefly luciferase reporter genes.

Figure 2 shows food intake (left), body weight (middle) and blood glucose (right) in db/db mice after a single intraperitoneal injection of R1Mab2 or control IgG at a dose of 3 mpk on day 0. Control mice were pair fed (PF) with adjusted food intake until day 11. On day 11, the food intake of R1MAb2-treated mice returned to normal, so all mice were fed ad libitum after day 11 (AL). N=7～12. p<0.001.

Figure 3 shows a GAL-Elk based luciferase assay in HEK293 cells expressing FGFRlc to compare R1MAb2 and a DNA mutant of R1MAb2 (R1MAb2 DANA).

FuncS

Figure 4 shows the body weight of db/db mice after a single intraperitoneal injection of the indicated doses of R1MAb2 (labeled 182.2), R1MAb3 (labeled 182.5), or control IgG (anti-Her2) (bottom).