iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639)

Q: We are using this antibody for in Vivo experiment, can you provide the antibody with endotoxin <1 EU/mg?

Yes, we provide customized antibody production and can provide endotoxin-low (<1EU/mg).

Q: What is the recommended concentration for using this antibody in flow cytometry?

For flow cytometry applications, we recommend using the antibody at a concentration of 1-10 µg/mL. However, optimal concentrations may vary depending on the specific experimental conditions and cell types used. It is advisable to perform a titration experiment to determine the best concentration for your particular setup.

Q: Can this antibody be used for in vivo experiments?

Yes, the antibody is suitable for in vivo studies. It has been successfully used in various in vivo models to investigate the function and role of GARP. When planning in vivo experiments, ensure proper administration routes and dosages to achieve the best results while minimizing any potential off-target effects.

Q: How does the antibody perform in blocking assays?

The antibody has demonstrated excellent performance in blocking assays. It effectively inhibits the interaction of GARP with its ligands, allowing researchers to study the functional consequences of this blockade.

Product Overview

Description

The antibody directed against human GARP; inhibits active TGF-β production by human Treg cells. The antibody does not bind mGARP. Its binding to hGARP requires a region comprising amino-acids 101 to 141.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Mouse

Applications

FC; Inhib; Block; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

GARP

Official Name

LRRC32

Full Name

Leucine Rich Repeat Containing 32

Alternative Names

Leucine Rich Repeat Containing 32; Glycoprotein A Repetitions Predominant; Transforming Growth Factor Beta Activator LRRC3; Leucine-Rich Repeat-Containing Protein 3; D11S833E; Garpin; GARP; LRRC32

Gene ID

2615(Human); 434215(Mouse)

Uniprot ID

Q14392(Human)

Publications

Publications (0)

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Scientific Resources

[Brochure]

Neuros Antibody Product Panel

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Customer Reviews and Q&As

Customer Reviews Average Customer Ratings Overall

5.0

Excellent

The antibody's stability and reproducibility are commendable

The antibody's ability to specifically inhibit GARP has been critical for our research on immune regulation. We observed significant changes in our experimental outcomes, which have opened new avenues for exploration.

Excellent

For blocking experiments in vitro

Its effectiveness in flow cytometry has allowed us to accurately analyze cell populations, providing deeper insights into our studies. The antibody's high specificity and affinity for GARP have made it an indispensable tool in our lab.

Excellent

A robust and reliable antibody

The specificity of the antibody is impressive, and it has significantly contributed to the success of our experiments. We appreciate the consistent performance and the quality of results it provides.

Excellent

We've had great success with the antibody

The antibody's effectiveness in blocking GARP has been crucial for our studies on immune modulation. Its specificity and reproducibility have allowed us to generate reliable data.

Excellent

In our lab, we have been using the antibody for various applications

The antibody consistently produces clear and specific staining, with minimal background noise. Its performance in in vitro inhibition studies has also been noteworthy, providing valuable insights into GARP's role in our research focus.

Q&As

We are using this antibody for in Vivo experiment, can you provide the antibody with endotoxin <1 EU/mg?

Yes, we provide customized antibody production and can provide endotoxin-low (<1EU/mg).

What is the recommended concentration for using this antibody in flow cytometry?

For flow cytometry applications, we recommend using the antibody at a concentration of 1-10 µg/mL. However, optimal concentrations may vary depending on the specific experimental conditions and cell types used. It is advisable to perform a titration experiment to determine the best concentration for your particular setup.

Can this antibody be used for in vivo experiments?

Yes, the antibody is suitable for in vivo studies. It has been successfully used in various in vivo models to investigate the function and role of GARP. When planning in vivo experiments, ensure proper administration routes and dosages to achieve the best results while minimizing any potential off-target effects.

How does the antibody perform in blocking assays?

The antibody has demonstrated excellent performance in blocking assays. It effectively inhibits the interaction of GARP with its ligands, allowing researchers to study the functional consequences of this blockade.