NeuroMab™ Anti-GFP (Green fluorescent protein) BBB Shuttle Antibody, Clone N86/38

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GFP BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-238 (full-length) of jellyfish green fluorescent protein (also known as GFP; accession number P42212)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Wide Species

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N86/38

Applications

WB; IHC; IP; ICC

Application Notes

Cross-reacts with Cyan and Yellow fluorescent protein (CFP and YFP, respectively);Does not cross-react with Red fluorescent protein (dsRed)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GFP

Official Name

GFP

Full Name

GFP

Alternative Names

GFP;Green fluorescent protein

Uniprot ID

P42212

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transfected with GFP; GFP-tagged HCN2, FGF11/FHF3, FGF13/FHF2 and BKBeta2; or untagged Kv2.1 plasmid and probed with N86/38 TC supe.

Fig. 2 Transfected cell immunoblot: extracts of COS cells transfected with GFP-tagged MHC, CFP-tagged MHC, YFP-tagged Histone H3.3 or untagged Kv2.1 plasmid and probed with N86/38 (left) or N52A/42 (right) TC supe.