NeuroMab™ Anti-IL-10 Antibody (NRP-0422-P1496)
Functional antibody against Human IL10
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- ELISA; In Vitro; In Vivo
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryDescription
Species Reactivity
Clonality
Host Species
Applications
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 provides a comparison of the antigen binding properties of humanized antibody variants with chimeric cB-N10 antibody using hIL-10 antigen ELISA.
Figure 2 presents the results of an assay of the binding properties of the three humanized variants hVH20/hVL7, hVH20/hVL8 and hVH26/hVL7 compared to chimeric B-N10 antibodies using purified antibody preparations.
Figure 3 shows the level of TNFalpha release in whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).
Figure 4 shows the release levels of IL-6 from whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).
Figure 5 shows the release levels of IL-1beta from whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).
Figure 6 shows the levels of IFNγ released from whole blood cultures of healthy volunteers after incubation with B-N10 compared to BT-063 (50 μg/ml).
Figure 7 shows the mean cmax of cytokine concentrations in plasma following administration of BT-063 to healthy volunteers as a function of dose.
Figure 8 is a graph showing the mean concentration of IL-10 in plasma over time after administration of BT-063 in healthy volunteers.
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