NeuroMab™ Anti-IL-6 BBB Shuttle Antibody(NRZP-1022-ZP2900)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Humanized

Applications

ELISA; Block; Inhib; In Vitro

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Product Pictures

ELISA

Figure 1 shows the competition ELISA analysis of BA001 and anti-IL-6 antibodies.

Inhib

Figure 2 shows the inhibition of IL-6/sIL6R-induced Stat3 phosphorylation in THP-1 cells by increasing the concentration of anti-IL-6 monoclonal antibody. Data were normalized based on western blot of total Stat3.

Inhib

Figure 3 shows the phosphorylation of Stat3 in THP-1 cells stimulated with IL-6/sIL-6R by various anti-IL6 mAbs including 003, BA399, BA399-2 and BA399-9 (A) using 100 ng/mL IL- The inhibitory effect of 6.

Inhib

Figure 4 shows the effect of serially diluted anti-IL-6 monoclonal antibodies CNTO136, BA399, BA399-2, BA399-9 on the production of serum amyloid A by HepG2 cells stimulated with human IL-6, sIL-6R and IL-1b Inhibition at 24 hours.

Inhib

Figure 5 After serial dilution of anti-IL-6 monoclonal antibodies CNTO136, BA399, BA399-2, BA399-9, HepG2 cells stimulated with human IL-6, sIL-6R and IL-1b inhibited serum amyloid A at 48 Hour.

Inhib

Figure 6 shows the inhibition of IL-6-induced proliferation of DS-1 cells by anti-IL-6 monoclonal antibodies BA001, BA399, BA436, BA802, BA808, BA840, BA848 and BA890 at 48 hours.

Inhib

Figure 7 shows the inhibition of IL-6-induced proliferation of DS-1 cells by anti-IL-6 monoclonal antibodies BA001, BA399, BA436, BA802, BA808, BA840, BA848 and BA890 at 96 hours.

Publications