NeuroMab™ Anti-IL-6R BBB Shuttle Antibody(NRZP-1022-ZP2913)
[CAT#: NRZP-1022-ZP2913]
- Host Species:
- Rabbit; Humanized
- Species Reactivity:
- Human
- Applications:
- FC; Inhib; Block; In Vitro; In Vivo; Neut
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rabbit; Humanized
Applications
FC; Inhib; Block; In Vitro; In Vivo; Neut
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
CD126
Official Name
IL6R
Full Name
Interleukin 6 (IL-6)
Alternative Names
IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6
Product Pictures
ELISA
Figure 1 Humanized lead anti-IL-6R antibody candidates retain most of the activity of their rabbit counterparts.
Direct ELISA of anti-IL-6R antibodies.
FCM
Figure 2 Humanized lead anti-IL-7R antibody candidates retain most of their rabbit antibody activity.
Anti-IL-6R antibody binding to IL-6R on human myeloma U266B1 cells measured by FACS
Block
Figure 3 Humanized lead anti-IL-8R antibody candidates retain most of the activity of their rabbit counterparts.
Ability of anti-IL-6R antibodies to block IL-6 binding to IL-6R.
FuncS
Figure 4 Humanized lead anti-IL-9R antibody candidates retain most of the activity of their rabbit counterparts.
Humanized anti-IL-6R antibodies inhibit IL-6 mediated proliferation of TF-1 cells.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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