NeuroMab™ Anti-Mitofusin-2 (Mfn2) BBB Shuttle Antibody, Clone N153/5
[CAT#: NRZP-0423-ZP271]
- Species Reactivity:
- Rat; Mouse
- Applications:
- WB; IHC; ICC
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Mitofusin 2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2 (also known as Transmembrane GTPase Mfn2, Hypertension-related protein 1, Mitochondrial assembly regulatory factor, Mitochondrial transmembrane GTPase FZO1A and Protein HSG, accession number Q80U63)
Rat: 97% identity (226/231 amino acids identical)
Human: 92% identity (214/231 amino acids identical)
~55% identity with Mitofusin-1
Rat: 97% identity (226/231 amino acids identical)
Human: 92% identity (214/231 amino acids identical)
~55% identity with Mitofusin-1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N153/5
Applications
WB; IHC; ICC
Application Notes
No cross-reactivity against Mitofusin-1
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
Mitofusin 2
Official Name
MFN2
Full Name
Mitofusin-2
Alternative Names
MFN2; CMT2A; CMT2A2; CPRP1; HSG; MARF; HMSN6A; mitofusin 2; CMT2A2A; CMT2A2B
Uniprot ID
Q80U63
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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