NeuroMab™ Anti-Mitofusin-2 (Mfn2) BBB Shuttle Antibody, Clone N153/5

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Mitofusin 2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2 (also known as Transmembrane GTPase Mfn2, Hypertension-related protein 1, Mitochondrial assembly regulatory factor, Mitochondrial transmembrane GTPase FZO1A and Protein HSG, accession number Q80U63)
Rat: 97% identity (226/231 amino acids identical)
Human: 92% identity (214/231 amino acids identical)
~55% identity with Mitofusin-1

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N153/5

Applications

WB; IHC; ICC

Application Notes

No cross-reactivity against Mitofusin-1

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Mitofusin 2

Official Name

MFN2

Full Name

Mitofusin-2

Alternative Names

MFN2; CMT2A; CMT2A2; CPRP1; HSG; MARF; HMSN6A; mitofusin 2; CMT2A2A; CMT2A2B

Uniprot ID

Q80U63

Product Pictures

Fig. 1 Immunoblot versus crude cardiac mitochondrial preps from WT, Mfn1 KO or Mfn2 KO mice and probed with N153/5 TC supe (top) and Porin antibody (bottom).