NeuroMab™ Anti-Nav1.6 sodium channel BBB Shuttle Antibody, Clone K87A/10

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN8A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number NP_062139)
Human: 88% identity (16/18 amino acids identical)
Mouse=100% identity (18/18 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K87A/10

Applications

WB; IHC; IP; ICC

Research Areas

Na+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SCN8A

Official Name

SCN8A

Full Name

Nav1.6 Na+ channel

Alternative Names

SCN8A; CERIII; CIAT; EIEE13; MED; NaCh6; Nav1.6; PN4; sodium voltage-gated channel alpha subunit 8; BFIS5; MYOCL2

Uniprot ID

NP_062139

Product Pictures

Fig. 1 Adult rat optic nerve immunofluorescence staining K87A/10=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband (Baylor College of Medicine).

Fig. 2 Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null“Null” mice. K87A/10=green. DAPI=blue. Scale bar=20 µm.

Publications