NeuroMab™ Anti-Neurexin-1-Beta BBB Shuttle Antibody, Clone N170A/1

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Neurexin 1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 51-68 (ASSLGAHHIHHFHGSSKH, extracellular N-terminus) of human Neurexin-1-Beta (also known as NRXN1, accession number P58400)
Mouse: 100% identity (18/18 amino acids identical)
Rat: 100% identity (18/18 amino acids identical)
>65% identity with Neurexin-2-Beta and Neurexin-3-Beta

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N170A/1

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Neurexin-2-Beta

Research Areas

CAMs

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Neurexin 1

Official Name

NRXN1

Full Name

Neurexin-1-Beta

Alternative Names

NRXN1; Hs.22998; PTHSL2; SCZD17; neurexin 1

Uniprot ID

P58400

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with Flag-tagged Neurexin-1-Alpha, Neurexin-1- Beta or untagged Kv2.1 plasmid and probed with N170A/1 TC supe.

Fig. 2 Transfected cell immunoblot: extracts of COS cells transiently transfected with Flag-tagged Neurexin-1-Alpha, Neurexin-1- Beta or untagged Kv2.1 plasmid and probed with rabbit anti-Flag.

Publications