NeuroMab™ Anti-NKCC1 BBB Shuttle Antibody, Clone N161/20

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SLC12A2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 208-223 (YYLR[pT]FGHN[pT]MDAVPR) of human NKCC1 (also known as Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, Solute carrier family 12 member 2 and Slc12a2, accession number P55011)
Mouse: 100% identity (16/16 amino acids identical)
Rat: 100% identity (16/16 amino acids identical)
>90% identity with NKCC2
>70% identity with NKCC3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N161/20

Applications

Application Notes

Cross-reacts with non-phosphorylated peptide

Research Areas

Transporters

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SLC12A2

Official Name

SLC12A2

Full Name

NKCC1

Alternative Names

NKCC1

Uniprot ID

P55011

Product Pictures

Fig. 1 Serial dilutions of BSA-conjugated modified and unmodified peptides dotted onto membrane and probed with N161/20 TC supe (left) and a mouse loading control (right).

Publications