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Creative Biolabs
Product

NeuroMab™ Anti-RAGE Antibody, Clone 11E6

[CAT#: NRP-0422-P545]

A functional antibody raised against Human RAGE.

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; FC; IHC; In Vitro; In Vivo

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Product Overview

Description

The isolated monoclonal antibody binds to the epitope of a human RAGE molecule. It's capable of being used in the treatment and diagnosis of Alzheimer's disease (AD), central nervous system cell degeneration, learning and memory impairment, abnormal transport of amyloid β, and other neurological inflammatory symptoms associated with a receptor for advanced-glycation-end-products (RAGE).

Immunogen

C2 domain

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

11E6

Applications

ELISA; FC; IHC; In Vitro; In Vivo
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

RAGE

Official Name

AGER

Full Name

advanced glycosylation end product-specific receptor

Alternative Names

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor; and besides AGE; interacts with other molecules implicated in homeostasis; development; and inflammation; and certain diseases; such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms; as well as non-protein-coding variants; have been described for this gene.

Gene ID

177(Human); 11596(Mouse); 81722(Rat)

Uniprot ID

Q15109(Human); Q62151(Mouse); Q63495(Rat)
Product Pictures
ELISA

Figure 1 shows ELISA binding of recombinant and hybridoma-derived anti-human RAGE monoclonal antibodies to recombinant human RAGE.

Both C320-168 and C320-179 bind to the longer (72-251) and shorter (84-251) isoforms of soluble split TL1a.

DB

Figure 2 shows the characterization of mAb binding pairs by dot blot.

Both C320-168 and C320-179 bind to the longer (72-251) and shorter (84-251) isoforms of soluble split TL1a.

FuncS

Figure 3 shows the effect of 11E6 on changes in cerebral blood flow induced by Aβ1-40.

Both C320-168 and C320-179 bind to the longer (72-251) and shorter (84-251) isoforms of soluble split TL1a.

FuncS

Figure 4 shows that antibody 11E6 protects hippocampal neurons from Aβ-induced dynamin cleavage.

Both C320-168 and C320-179 bind to the longer (72-251) and shorter (84-251) isoforms of soluble split TL1a.

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