NeuroMab™ Anti-SCN9A Antibody(NRP-0422-P563)
[CAT#: NRP-0422-P563]
A functional antibody raised against Human, Mouse Nav1.7.
- Host Species:
- Rabbit
- Species Reactivity:
- Human; Mouse
- Applications:
- ELISA; Block; Inhib; In Vivo; In Vitro
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Lot Number
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Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Antibody NRP-0422-P563 specific binding to Nav 1.7 peptide. Antibody 1080 reduces electrically induced DRG spike frequency in vitro.
Immunogen
The antibody binds to Human and Mouse domain B.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Rabbit
Applications
ELISA; Block; Inhib; In Vivo; In Vitro
Relevant Diseases
Pain; Epilepsy
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
>95% by SDS PAGE or HPLC
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Target
SCN9A
Official Name
SCN9A
Full Name
sodium voltage-gated channel alpha subunit 9
Alternative Names
SCN9A; ETHA; FEB3B; GEFSP7; HSAN2D; NE-NA; NENA; Nav1.7; PN1; SFNP; sodium voltage-gated channel alpha subunit 9
Product Pictures
ELISA
Figure 1 shows that anti-Nav1.7 monoclonal antibody 1080 reduces the frequency of electrically induced DRG spikes in vitro.
983 mAb produces dose-dependent inhibition of Nav1.7 currents.
ELISA
Figure 2 shows the automated patch clamp analysis of recombinant human Nav1.7 channels expressed in HEK cells. 1080 mAb produces dose-dependent inhibition of Nav1.7 currents.
983 mAb produces dose-dependent inhibition of Nav1.7 currents.
ELISA
Figure 3 shows the automated patch clamp analysis of recombinant rat Nav1.7 channels expressed in HEK cells.
1080 mAb produced about 26% inhibition of Nav1.7 current at 25 μg/ml.
ELISA
Figure 4 shows that antibody 1080 binds human and mouse domain B-loop El peptides.
1080 mAb produced about 26% inhibition of Nav1.7 current at 25 μg/ml.
ELISA
Figure 5 shows ELISA data for antibody 1080 binding specifically to Nav 1.7 peptide.
1080 mAb produced about 26% inhibition of Nav1.7 current at 25 μg/ml.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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