NeuroMab™ Anti-SEZ6 BBB Shuttle Antibody, Clone NR26P
- Host Species:
- Mouse
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- FC; IHC; In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Fig.1 show the detection by flow cytometry of the expression of the SEZ6 protein in NTX tumor cells using various anti-SEZ6 antibodies.
The X axis corresponds to the concentration of 3E antibody (Fab) and the Y axis corresponds to NGF binding (percentage of maximum UR). Increased concentrations of Fab E3 blocked the interaction of NGF with both p75 and trkA, as shown by signal reduction (measured in UR). When the concentration of E3 antibody (Fab) was equalized with the concentration of NGF, no NGF binding was observed (as shown by a zero signal).
Fig.2 shows the results of an in vitro destruction assay using anti-SEZ6 ADC in HEK293 cells that overexpress SEZ6.
The X axis corresponds to the concentration of 3E antibody (Fab) and the Y axis corresponds to NGF binding (percentage of maximum UR). Increased concentrations of Fab E3 blocked the interaction of NGF with both p75 and trkA, as shown by signal reduction (measured in UR). When the concentration of E3 antibody (Fab) was equalized with the concentration of NGF, no NGF binding was observed (as shown by a zero signal).
Fig.3 shows the effect of anti-SEZ6 ADC on the in vivo growth of SCLC (LU86) and LCNEC (Lu50) tumors.
The X axis corresponds to the concentration of 3E antibody (Fab) and the Y axis corresponds to NGF binding (percentage of maximum UR). Increased concentrations of Fab E3 blocked the interaction of NGF with both p75 and trkA, as shown by signal reduction (measured in UR). When the concentration of E3 antibody (Fab) was equalized with the concentration of NGF, no NGF binding was observed (as shown by a zero signal).
Fig.4 represents the ability of conjugated humanized anti-SEZ6 antibodies to retard the growth in vivo of four SCLC tumors (LU80, LU64, LU111 and LU117) and achieve lasting remission in immunosuppressed mice.
The X axis corresponds to the concentration of 3E antibody (Fab) and the Y axis corresponds to NGF binding (percentage of maximum UR). Increased concentrations of Fab E3 blocked the interaction of NGF with both p75 and trkA, as shown by signal reduction (measured in UR). When the concentration of E3 antibody (Fab) was equalized with the concentration of NGF, no NGF binding was observed (as shown by a zero signal).
Fig.5 represents the ability of conjugated humanized anti-SEZ6 antibodies to retard the growth in vivo of four SCLC tumors (LU80, LU64, LU111 and LU117) and achieve lasting remission in immunosuppressed mice.
The X axis corresponds to the concentration of 3E antibody (Fab) and the Y axis corresponds to NGF binding (percentage of maximum UR). Increased concentrations of Fab E3 blocked the interaction of NGF with both p75 and trkA, as shown by signal reduction (measured in UR). When the concentration of E3 antibody (Fab) was equalized with the concentration of NGF, no NGF binding was observed (as shown by a zero signal).
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