NeuroMab™ Anti-SOD1 Antibody(NRP-0422-P649)
A functional antibody raised against Human SOD1.
- Host Species:
- Human
- Species Reactivity:
- Human
- Applications:
- ELISA; FC; IHC; In Vitro; In Vivo
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Species Reactivity
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Endotoxin Level
Low Endotoxin < 1 EU/mg
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Research Use Only
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Figure 1 Binding specificity of human antibody to human recombinant SOD1.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.
Figure 3 Antibodies preferentially bind misfolded/aggregated human SOD1.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.
Figure 2 Binding specificity of human antibody to human recombinant SOD1.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.
Figure 4 NI-204.10A8 shows prominent staining of SOD1 pathology, including cytoplasmic SOD1 inclusions, mainly in motor neurons and extracellular SOD1 aggregates.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.
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