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Creative Biolabs

NeuroMab™ Anti-SOD1 Antibody(NRP-0422-P649)

[CAT#: NRP-0422-P649]

A functional antibody raised against Human SOD1.

Host Species:
Human
Species Reactivity:
Human
Applications:
ELISA; FC; IHC; In Vitro; In Vivo

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Product Overview

Description

The human anti-SOD1 antibody is useful for treating diseases associated with misfolded / aggregated SOD1, such as ALS (ALS).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

ELISA; FC; IHC; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

SOD1

Official Name

SOD1

Full Name

superoxide dismutase 1

Alternative Names

SOD1; ALS; ALS1; HEL-S-44; IPOA; SOD; hSod1; homodimer; superoxide dismutase 1; soluble; superoxide dismutase 1; STAHP
Product Pictures
ELISA

Figure 1 Binding specificity of human antibody to human recombinant SOD1.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

ELISA

Figure 3 Antibodies preferentially bind misfolded/aggregated human SOD1.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

ELISA

Figure 2 Binding specificity of human antibody to human recombinant SOD1.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

IHC

Figure 4 NI-204.10A8 shows prominent staining of SOD1 pathology, including cytoplasmic SOD1 inclusions, mainly in motor neurons and extracellular SOD1 aggregates.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

Publications

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