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Creative Biolabs
Product

NeuroMab™ Anti-SOD1 Antibody, Clone 591-37

[CAT#: NRP-0422-P653]

A functional antibody raised against Human SOD1.

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; WB; IP; IHC; In Vitro; In Vivo

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Product Overview

Description

The anti-SOD1 antibody can be used for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

591-37

Applications

ELISA; WB; IP; IHC; In Vitro; In Vivo
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

SOD1

Official Name

SOD1

Full Name

superoxide dismutase 1

Alternative Names

SOD1; ALS; ALS1; HEL-S-44; IPOA; SOD; hSod1; homodimer; superoxide dismutase 1; soluble; superoxide dismutase 1; STAHP
Product Pictures
ELISA

Figure 1 shows the binding results of SOD1-specific antibodies to various SOD1 proteins determined by ELISA.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

WB

Figure 2 Immunoprecipitation of various hSOD1 proteins expressed in human cells by immunoblotting.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

IHC

Figure 3 shows the images of immunohistochemical staining of spinal cord tissues of various hSOD1 protein transgenic mice with ten SOD1-specific antibodies.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

FuncS

Figure 4 shows the mean body weight changes of B6SJL-Tg(SOD1G93A)1Gur/J mice treated with monoclonal antibodies.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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