NeuroMab™ Anti-Tau BBB Shuttle Antibody(NRZP-1022-ZP3113)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

HXPGGG or Tau 151-391/4R.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Humanized

Applications

IHC; ELISA; In Vitro

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Tau

Official Name

MAPT

Full Name

Tau Protein

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

ELISA

Figure 1: Chimeric and murine DC8E8 and Tau 151-391/4R combinations

ELISA

Figure 2: Humanized and chimeric DC8E8 and Tau 151-391/4R combinations. Antibodies co-expressing assembly-encoded DC8E8 RHA or DC8E8 RHB co-expressed with DC8E8 RKA or DC8E8 RKB were compared to antibody binding of fully aptamer antibodies.

ELISA

Figure 3: Combination of humanized and chimeric DC8E8 and Tau 151-391/4R: the Vk version is (the light is installed on the Chain together with what is).

IHC

Figure 4 Immunohistochemical staining of Alzheimer's disease brain tissue with humanized DC8E8 antibody (IgG1).

IHC

Figure 5 Immunohistochemical staining of FTDP-17 brain (mutated in R406W Tau) using humanized DC8E8 antibody (IgG1).

IHC

Figure 6 Immunohistochemical staining for corticobasal degeneration using humanized DC8E8 antibody (IgG1).

IHC

Figure 7 Immunohistochemical staining of stein-leventhal syndrome using humanized DC8E8 antibody (IgG4).

ELISA

Figure 8 Heat resistance of the candidate derivatized DC8E8 antibody: the purified antibody was heated at the commanded Clock temperature for 10 points, then cooled to 4°C, and then Tau combined ELISA was performed.

Publications