NeuroMab™ Anti-Tau BBB Shuttle Antibody(NRZP-1022-ZP3115)

Figure 1: Chimeric and murine DC8E8 and Tau 151-391/4R combinations

Figure 2: Humanized and chimeric DC8E8 and Tau 151-391/4R combinations. Antibodies co-expressing assembly-encoded DC8E8 RHA or DC8E8 RHB co-expressed with DC8E8 RKA or DC8E8 RKB were compared to antibody binding of fully aptamer antibodies.

Figure 3: Combination of humanized and chimeric DC8E8 and Tau 151-391/4R: the Vk version is (the light is installed on the Chain together with what is).

Figure 4 Immunohistochemical staining of Alzheimer's disease brain tissue with humanized DC8E8 antibody (IgG1).

Figure 5 Immunohistochemical staining of FTDP-17 brain (mutated in R406W Tau) using humanized DC8E8 antibody (IgG1).

Figure 6 Immunohistochemical staining for corticobasal degeneration using humanized DC8E8 antibody (IgG1).

Figure 7 Immunohistochemical staining of stein-leventhal syndrome using humanized DC8E8 antibody (IgG4).

Figure 8 Heat resistance of the candidate derivatized DC8E8 antibody: the purified antibody was heated at the commanded Clock temperature for 10 points, then cooled to 4°C, and then Tau combined ELISA was performed.