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Creative Biolabs

NeuroMab™ Anti-Tau BBB Shuttle Antibody(NRZP-1022-ZP3139)

[CAT#: NRZP-1022-ZP3139]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
WB; ELISA; In Vitro; In Vivo

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; ELISA; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

Tau

Official Name

MAPT

Full Name

Tau Protein

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40
Product Pictures
FuncS

Figure 1 shows the abbreviated tau for antibodies at 1:1000, 1:3000, 1:9000, 1:27000 and 1:81000 antibody dilutions. Immunospecificity for the Asp421 epitope is shown.

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Figure 2 shows mixed cortical cultures of JNPL3 mice pretreated with PHF (1 μg/ml) against antibody 5G2A3 and antibody 1G11A10 (10 μg/ml) over time.

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Figure 3 shows mixed cortical cultures of JNPL3 mice pretreated with PHF (1 μg/ml) against antibody 5G2A3 and antibody 1G11A10 (10 μg/ml) over time.

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Figure 4 Effect of immunospecific binding of antibody to truncated tau Asp421 epitope.

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Figure 5 Significant reductions in Iba1 levels were observed at 72 and 96 h in mixed cortical cultures treated with antibody 5G2A3 compared to cells treated with control and PHF only.

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Figure 6 Effect of antibodies that can bind mixed neuronal cultures.

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Figure 7 Co-incubation of antibody 1G11A10 antibody with PHF failed to demonstrate any significant changes in phospho-tau levels compared to cells treated with PHF alone and PHF + IgG at all time points.

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Figure 8 Among antibodies 5G2A3 and 1G11A10, only antibody 5G2A3 was found to effectively reduce total tau levels.

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Figure 9 Co-incubation of antibody 5G2A3 with PHF did not reveal any significant change in Iba1 levels compared to untreated control cells, whereas a significant increase in Iba1 levels was observed in PHF only, PHF + IgG and cells treated with PHF + Antibody 1G11A10.

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