NeuroMab™ Anti-TDP43 Antibody(NRP-0422-P707)

Product Overview

Description

The mouse monoclonal antibody binds to the N-terminal epitope of TDP-43.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; IHC; ICC; Inhib; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TDP43

Official Name

TDP-43

Full Name

TAR DNA binding protein

Alternative Names

TDP-43; TAR DNA binding protein

Gene ID

23435(Human); 230908(Mouse); 298648(Rat)

Uniprot ID

Q13148(Human); Q921F2(Mouse)

Product Pictures

Block

Figure 2 shows that antibodies block delivery of misfolded TDP-43 in HEK293 cells.

Immunofluorescent staining of human TDP-43 and TDP-43 oligomers in brain sections of wild-type and 6- and 12-month-old TDP-43 Tg+/+ transgenic mice. Cells with anti-TDP oligomer staining, TDP-43 staining, and DAPI staining are shown (scale bar, 100 μm). Closed regions are presented at higher magnification in the last column (scale bar, 25 μm).

Publications