NeuroMab™ Anti-TDP43 BBB Shuttle Antibody(NRZP-1022-ZP2621)
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; IHC; ICC; Inhib; In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Fig.1 depicts that TDP-0 antibody recognizes TDP-43 oligomers specifically.
The 1 ml SEC fractions were collected and subjected to dot blotting by TDP-0 (upper blot) and N -26o antibodies (lower blot).
Fig.2 depicts that TDP-43 oligomers are present in FTLD-TDP patients.
TDP-0 antibody, in contrast to antibodies for monomeric TDP-43, did not stain nuclei demonstrating specificity toward misfolded TDP-43. Scale bars in all panels are 20 μιη.
Fig.3 depicts that TDP-0 mAbs exhibit higher specificities toward TDP-43 oligomer.
Various concentrations of TDP-0 mAbs (1 -2 x 10"^g/mL) respectively produced by TDP-O-3, -5, -8, -9, and -10 hybridoma cells were used in ELISA assay to detect the SDS denatured or non-denatured TDP-43.
Fig.4 depicts that TDP-0 mAbs exhibit higher specificities toward purified TDP-43 oligomer.
Conditional medium of TDP-O-3, -5, -8, -9, and -10 hybridoma cell lines were used to detect the TDP-43 oligomers and monomers by ELISA assay.
Fig.5 depicts that TDP-0 monoclonal antibody rescues TDP-43 oligomers-induced cytotoxicity.
MTT assay was performed to examine cell viability of BE(2)-C cells. Data are presented as mean ± standard deviation. Statistical analysis was performed by one-way ANOVAs, *p< 0.05, **p< 0.01 , ***p< 0.001 . The result showed the toxicity induced by TDP-43 oligomers was significantly rescued by the treatment of TDP-0 antibody.
Fig.6 depicts that TDP-43 oligomers are present and increase with age in transgenic mouse model of FTLD-TDP.
Immunofluorescent staining of human TDP-43 and TDP-43 oligomers in the brain slices of wild type and 6- and 12-month-old TDP-43 Tg+/+ transgenic mice. Cells with anti-TDP oligomer staining, TDP-43 staining, and DAPI staining are shown (scale bar, 100 μιη). Blocked area was presented at higher magnification in the last column (scale bar, 25 μιη).
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