NeuroMab™ Anti-TrpV1 BBB Shuttle Antibody, Clone N221/17
[CAT#: NRZP-0423-ZP447]
- Species Reactivity:
- Rat; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VR1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1-160 (cytoplasmic N-terminus) of rat TrpV1 (also known as Transient receptor potential cation channel subfamily V member 1, Osm-9-like TRP channel 1, OTRPC1, Capsaicin receptor, Vanilloid receptor 1, VR1, Vanilloid receptor type 1-like and Vr1l, accession number O35433)
Mouse: 85% identity (137/161 amino acids identical)
Human: 68% identity (110/161 amino acids identical)
<50% identity with TrpV4
Mouse: 85% identity (137/161 amino acids identical)
Human: 68% identity (110/161 amino acids identical)
<50% identity with TrpV4
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N221/17
Applications
WB; IHC; ICC
Research Areas
Trp channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
VR1
Official Name
TRPV1
Full Name
TrpV1
Alternative Names
TRPV1; VR1; transient receptor potential cation channel subfamily V member 1
Uniprot ID
O35433
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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