NeuroMab™ anti-TfR1 VNAR BBB Shuttle antibody(NRZP-1022-ZP4064)
[CAT#: NRZP-1022-ZP4064]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- In Vitro
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Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
In Vitro
Relevant Diseases
Tumor
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
TransferrinReceptor
Official Name
TfR
Full Name
Transferrin Receptor
Alternative Names
CD71; TFR1
Product Pictures
FuncS
Figure 1 TXB2 VNAR analysis
FuncS
Figure 2 In vivo study of TXB2 in AβPP transgenic mice.
FuncS
Figure 3. In vivo functional activity of TXB2 variants correlates with in vitro TfR1 binding.
IHC
Figure 4 IHC assessment of TXB4 shuttling brain penetration.
FuncS
Figure 5 Brain-specific biodistribution of TXB4 and pharmacodynamic activity of TXB4 fused to NT.
FuncS
Figure 6 TXB4 is highly effective in delivering therapeutic antibodies to the brain.
IHC
Figure 7 IHC assessment of antibody delivery to the brain parenchyma using the TXB4 shuttle.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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