Mouse Anti-GFAP Monoclonal Antibody (CBP1511)

Product Overview

Description

Mouse anti-human glial fibrillary acidic protein antibody, clone GF-05 can recognize human glial fibrillary acidic protein (GFAP). GFAP is an intermediate filament protein of 432 amino acids. Mouse anti-human glial fibrillary acidic protein antibody, clone GF-05, can recognize neurofilaments of about 38-45 kDa in western blot. Mouse anti-human glial fibrillary acidic protein antibody, clone GF-05 is also reactive in ELISA, the antigen coating concentration is 5μg/ml, and may react with GFAP of other species. Mutations in GFAP gene may cause Alexander disease (ALXDRD), a rare neurological disease affecting infants, is characterized by myelin failure leading to early death.

Immunogen

Native GFAP purified from human brain.

Species Reactivity

Human; Cynomolgus monkey

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP1511

Applications

ELISA; WB

Relevant Diseases

Alexander's Disease

Research Areas

Growth and Development

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS
0.09% Sodium Azide

Concentration

1 mg/ml

Purification

Purified IgG prepared by affinity chromatography on Protein G.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Target

GFAP

Official Name

GFAP

Full Name

Glial Fibrillary Acidic Protein

Alternative Names

Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;

Gene ID

2670(Human); 14580(Mouse); 24387(Rat)

Uniprot ID

P14136(Human); P03995(Mouse); P47819(Rat)

References

1. Burbaeva, G.Sh. et al. (2007) Systemic neurochemical alterations in schizophrenic brain: glutamate metabolism in focus.
2. Gil-Perotin, S. et al. (2009) Ultrastructure of the subventricular zone in Macaca fascicularis and evidence of a mouse-like migratory stream.
3. Wei, P. et al. (2013) Serum GFAP autoantibody as an ELISA-detectable glioma marker.
4. Garbayo, E. et al. (2016) Brain delivery of microencapsulated GDNF induces functional and structural recovery in parkinsonian monkeys.
5. Martinez-Valbuena, M. et al. (2019) Amylin as a potential link between type 2 diabetes and alzheimer disease.

Publications