Product
Mouse Anti-RYR1 Monoclonal Antibody (CBP1599)
[CAT#: NAB2007FY324]
Mouse Monoclonal [RYR.1 (G-1)] to RYR1
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Dog; Bovine; Porcine; Rat
- Applications:
- ELISA; IF; IHC-Fr; WB; FC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Mouse anti-human Ryanodine receptor antibody, clone RYR-1 recognizes human ryanodine receptor 1, also known as skeletal muscle calcium release channel or skeletal muscle ryanodine receptor. Ryanodine receptor 1 is a large 5038 amino acid, approximately 500 kDa multichannel transmembrane protein associated with the sarcoplasmic reticulum, containing three B30.2/SPRY domains and five MIR domains. Mouse anti-human Ryanodine receptor antibody, clone RYR-1 recognizes the epitope in the C-terminal cytoplasmic domain of ryanodine receptor (UniProt: P21817).
It has been shown that Ryanodine receptors play a key role in intracellular Ca2+ signaling that occurs during cell activation of muscle cells and non-muscle cells. Mouse anti-human Ryanodine receptor antibody RYR-1 clone and ryanodine isolated from various cell types (such as lymphocytes, macrophages, granulocytes, fibroblasts, epithelial cells, endothelial cells, skeletal muscle, cardiac muscle and brain tissue) Receptor response. Defects in the ryanodine receptor 1 gene are associated with malignant hyperthermia (Gillard et al., 1992), central muscle disease (Quane et al., 1993) and certain recessive myopathy.
It has been shown that Ryanodine receptors play a key role in intracellular Ca2+ signaling that occurs during cell activation of muscle cells and non-muscle cells. Mouse anti-human Ryanodine receptor antibody RYR-1 clone and ryanodine isolated from various cell types (such as lymphocytes, macrophages, granulocytes, fibroblasts, epithelial cells, endothelial cells, skeletal muscle, cardiac muscle and brain tissue) Receptor response. Defects in the ryanodine receptor 1 gene are associated with malignant hyperthermia (Gillard et al., 1992), central muscle disease (Quane et al., 1993) and certain recessive myopathy.
Immunogen
Short synthetic polypeptide corresponding to the C-terminal domain of the ryanodine receptor.
Species Reactivity
Human; Mouse; Dog; Bovine; Porcine; Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2b
Clone Number
CBP1599
Applications
ELISA; IF; IHC-Fr; WB; FC
Application Notes
ELISA (1/1000); FC (1/500); IF (1/100); IHC-Fr (1/100); IB (1/100)
Research Areas
Growth and Development
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS
0.01% Sodium Azide
0.01% Sodium Azide
Concentration
0.5 mg/ml
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.
Target
Target
RYR1
Official Name
RYR1
Full Name
Ryanodine Receptor 1
Alternative Names
Ryanodine Receptor 1; Protein Phosphatase 1, Regulatory Subunit 137; Skeletal Muscle Calcium Release Channel; Skeletal Muscle Ryanodine Receptor; Ryanodine Receptor 1 (Skeletal); Central Core Disease Of Muscle; RYR-1; RYDR; Sarcoplasmic Reticulum Calcium Release Channel; Skeletal Muscle-Type Ryanodine Receptor
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
