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Creative Biolabs

Mouse Anti-Beta Amyloid (CBP1931)

[CAT#: NAB2007FY357]

Mouse Monoclonal [MAb1.1] to Beta Amyloid (aa37-42)

Host Species:
Mouse
Species Reactivity:
Human
Applications:
ELISA; IHC-Fr; IHC-P

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Product Overview

Description

Mouse anti-human β-amyloid 42 antibody, clone Mab1.1 recognizes β-amyloid 42 (also known as Aβ42), which is a 42-amino acid peptide processed from amyloid precursor protein (APP). There are several forms of Aβ peptides processed by APP, the most common being Aβ40 and Aβ42. Amyloid plaques contain both Aβ40 and Aβ42. Aβ40 is more common, but Aβ42 is more fibrogenic and is therefore associated with diseases such as Alzheimer's disease.
Mouse anti-human β amyloid 42 antibody, clone Mab1.1 specifically binds to the 37-42aa region, and cannot recognize full-length APP or a 40 amino acid peptide (Aβ40) processed by APP. It can stain the diffuse plaques found in the brains of Alzheimer's disease patients. It will not stain healthy brain tissue or other organs.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP1931

Applications

ELISA; IHC-Fr; IHC-P

Application Notes

ELISA (0.2 ug/ml); IHC-Fr (20 ug/ml-40 ug/ml)

Relevant Diseases

Alzheimer's Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS; 0.09% Sodium Azide

Preservatives

Yes

Concentration

1.0 mg/ml

Purification

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

APP

Official Name

APP

Full Name

Amyloid Precursor Protein

Alternative Names

APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; amyloid beta precursor protein; preA4

Gene ID

351 (Human); 11820 (Mouse); 54226 (Rat)

Uniprot ID

P05067 (Human); P12023 (Mouse); P08592 (Rat)
References

1. Axelsen, T.V. et al. (2009) Specific recognition of the C-terminal end of A beta 42 by a high affinity monoclonal antibody.
Publications

Publications (0)

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