Mouse Anti-S100 Beta Monoclonal Antibody (CBP2174)

Product Overview

Description

S100B is glial-specific. It has been shown that it is only expressed by a subtype of mature astrocytes that ensheath blood vessels, and by NG2-expressing cells. This protein may function in neurite extension, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing central nervous system (CNS), it acts as a neurotrophic factor and neuronal survival protein. In the adult organism, it is usually elevated due to nervous system damage, which makes it a potential clinical marker. S100B is secreted by astrocytes or can spill from injured cells and enter the extracellular space or bloodstream. Serum levels of S100B increase in patients during the acute phase of brain damage. Over the last decade, S100B has emerged as a candidate peripheral biomarker of blood-brain barrier (BBB) permeability and central nervous system injury.

Immunogen

Full length recombinant human S100B protein.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2174

Applications

Application Notes

WB (0.5 -2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

S100 Beta

Official Name

S100B

Full Name

S100 calcium-binding protein B

Alternative Names

S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B

Gene ID

6285(Human); 20203(Mouse); 25742(Rat)

Uniprot ID

P04271(Human); P50114(Mouse); P04631(Rat)

References

1. Wang D, et al. 2008. Prog. Neurobiol. 86:342.
2. Michetti F, et al. 2012. J. Neurochem. 120:644.
3. Zongo D, et al. 2012. Annals. of Emergency Medicine 59:209.
4. Deloulme J, et al. 2000. J. Biol. Chem. 275:35302-10.

Publications