Mouse Anti-Rab6 Monoclonal Antibody (CBP2263)

[CAT#: NAB2010188LS]

Anti-Rab6 Monoclonal Antibody

Host Species:: Mouse

Species Reactivity:: Human; Rat

Applications:: WB

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Product Overview

Description

Rab proteins are small GTPases that are critical for the Golgi apparatus organization. Rab6 is the most abundant Golgi-associated Rab and is expressed in several isoforms, including Rab6aA, Rab6A', Rab6B, and Rab6C. Rab6A and Rab6A' are ubiquitously expressed while Rab6B is selectively expressed in neuronal cells. Rab6 isoforms are involved in intra-, early, and post-Golgi trafficking. Rab6 depletion leads to increased Golgi cisternal number and accumulation of vesicles in HeLa cells, suggesting that Rab6 affects the Golgi ribbon organization via regulation of vesicle transport.

Immunogen

Recombinant human Rab6A

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2263

Applications

Application Notes

WB (0.5-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Rab6

Official Name

RAB6A

Full Name

Ras-related protein Rab-6A

Alternative Names

Ras-related protein Rab-6A

Gene ID

5870 (Human); 19346 (Mouse)

Uniprot ID

P20340 (Human); P35279 (Mouse)

References

1. Liu S, et al. 2015. Int Rev Cell Mol Biol. 315:1
2. Heffernan LF, et al. 2014. Biochem Soc Trans. 42(5):1453
3. Fernandes H, et al. 2009. Biochem Soc Trans. 37:1037

Publications