Rat Anti-68kDa Neurofilament / NF-L Monoclonal Antibody (CBP2372)

Product Overview

Description

Neurofilaments (NF) are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Detection of NF, and the subunits of NF, may serve as a biomarker for axonal degeneration. The degree of axonal degeneration is related to the amount of NF detected in the cerebrospinal fluid (CSF) and the blood. Neurofilament light (NF-L) levels are elevated in Alzheimer's Disease.

Immunogen

Purified macaque NFL.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG1, κ

Clone Number

CBP2372

Applications

WB; IHC-P

Application Notes

WB (5.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Neurofilament L

Official Name

NEFL

Full Name

Neurofilament light polypeptide

Alternative Names

NEFL; CMT1F; CMT2E; NF-L; NF68; NFL; PPP1R110; neurofilament; light polypeptide; neurofilament light; CMTDIG

Gene ID

4747 (Human); 18039 (Mouse); 83613 (Rat)

Uniprot ID

P07196 (Human); P08551 (Mouse); P19527 (Rat)

References

1. Zetterberg H, Blennow K. 2015. JAMA Neurol. 11:1237-8.
2. Bäckström D, et al. 2015. JAMA Neurol. 72(10):1175.
3. Janelidze S, et al. 2015. Neurology 85:1834.
4. Magdalinou NK, et al. 2015. J. Neurol. Neurosurg. Psychiatry 86(11):1240.
5. Skillbäck T, et al. 2014. Neurology. 83:1945.

Publications