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Creative Biolabs

Rat Anti-Mouse CD45 Monoclonal Antibody (CBP2411)

[CAT#: NAB2010481LS]

Anti-CD45 Monoclonal Antibody

Host Species:
Rat
Species Reactivity:
Mouse
Applications:
FC

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Product Overview

Description

CD45.1 is an alloantigen of CD45, expressed by Ly5.1 bearing mouse strains (e.g., RIII, SJL/J, STS/A, DA). CD45, a member of the protein tyrosine phosphatase (PTP) family, is a 180-240 kD glycoprotein expressed on all hematopoietic cells except mature erythrocytes and platelets. There are multiple isoforms in mice that play key roles in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation states of the cell as well as specific cell types. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Immunogen

SJL mouse thymocytes and splenocytes

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG1, κ

Clone Number

CBP2411

Applications

FC

Application Notes

FCM (≤0.25 µg per million cells in 100 µl volume)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

CD45

Official Name

PTPRC

Full Name

Protein tyrosine phosphatase, receptor type, C

Gene ID

5788 (Human); 19264 (Mouse)

Uniprot ID

P08575 (Human); P08575 (Mouse)
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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