Rat Anti-ATG17 Monoclonal Antibody (CBP2463)

Product Overview

Description

RB1-inducible coiled-coil 1 (RB1CC1), also known as ATG17 or FIP200, was originally identified as a potent regulator of RB1 gene. RB1CC1 is a component of the ULK1-ATG13-RB1CC1 complex, which is required for the early events of autophagy and is inhibited by mTOR. RB1CC1 has been suggested to participate in the NF-kβ, mTOR, and FAK-Erk1/2 signaling pathways and regulates cell proliferation, apoptosis, and migration. RB1CC1 enhances transcription of RB1, p16, and p21 when forms a complex with p53, PIASy, and hSNF5. RB1CC1 plays an important role in tumor suppression by globally activation of the RB1 pathway. Aberrant expression or genetic alterations of RB1CC1 has been associates with various disease, including cancer, neuronal degeneration, skin inflammation, and anemia.

Immunogen

Recombinant human RB1CC1 (1345-1594 a.a.) expressed in E. coli.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP2463

Applications

Application Notes

WB (0.2-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

ATG17

Official Name

7ATG1

Full Name

RB1-inducible coiled-coil 1

Alternative Names

RB1-inducible coiled-coil protein 1; FAK family kinase-interacting protein of 200 Da;FIP200; ATG17; KIAA0203

References

1. Zhang LY, et al. 2016. Carcinogenesis. 37:320.
2. Yao J, et al. 2015. Autophagy. 11:939.
3. Suraneni MV, et al. 2014. Cell Cycle. 13:1798.
4. Morselli E, et al. 2011. Cell Cycle. 10:2763.
5. Ikebuchi K, et al. 2009. Int. J. Cancer. 125:861.
6. Chano T, et al. 2002. Nat Genet. 31:285.

Publications