NeuroMab™ Rat Anti-Human FBXO7 Monoclonal Antibody (CBP2465)
[CAT#: NAB2010569LS]
Anti-FBXO7 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- WB; ICC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
F-box only protein 7 (FBXO7) is involved in the ubiquitination process during protein degradation. FBXO7 is a subunit of the SCF (SKP1/cullin-1/F-box protein) complex. The scaffold proteins cullin-1 and SKP1, the RING subunit Rbx1 together with the substrate-recruiting subunit FBXO7 form a functional E3 ubiquitin ligase. FBXO7 is implicated in Parkinson's disease. In addition to reduced proteasome activity, loss of FBXO7 in mice leads to Parkinsonism-like phenotype. Human FBXO7 is mainly localized to the nucleus, while the mutation observed in patients with parkinsonian-pyramidal syndrome leads to impaired nuclear localization of this protein.
Immunogen
Human FBXO7 recombinant protein (1-250 a.a.) expressed in E. coli.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
CBP2465
Applications
WB; ICC
Application Notes
WB (0.5- 5.0 µg/mL); ICC (0.5- 5.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1804
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
Batch Dependent
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Vingill S, et al. 2016. EMBO J. 35: 2008-25.
2. Zhao T, et al. 2011. PLoS One. 6:e16983.
3. Zhou ZD, et al. 2015. Hum. Mol. Genet. 24:6314-30.
2. Zhao T, et al. 2011. PLoS One. 6:e16983.
3. Zhou ZD, et al. 2015. Hum. Mol. Genet. 24:6314-30.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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