NeuroMab™ Mouse Anti-Amyloid Beta 1-42 Monoclonal Antibody (CBP2476)

Product Overview

Description

Amyloid beta (Aβ or Amyloid beta) denotes peptides of 36-43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds") which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2476

Applications

IHC-P; ELISA

Application Notes

IHC-P (0.25-1.0 µg/mL); ELISA (0.01-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Product Properties

Form

Liquid

Formulation

PBS

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Amyloid Beta 1-42

Official Name

Amyloid Beta 1-42

Full Name

Amyloid beta

Alternative Names

APP; Aβ; Abeta; Amyloid β

Gene ID

351 (Human); 11820 (Mouse)

Uniprot ID

P05067 (Human); P12023 (Mouse)

References

1. Kumar A, et al. 2015. Pharmacol. Rep. 67(2):195.
2. Sadigh-Eteghad S, et al. 2015. Med. Princ. Pract. 24(1):1
3. Hampel H, et al. 2015. Expert Rev. Neurother. 15(1):83.
4. Puig KL, et al. 2012. Exp. Gerontol. 48(7): 608.
5. Selkoe DJ, et al. 2016. EMBO Mol. Med. 8(6):595.
6. Walsh DM, et al. 2007. J. Neurochem. 101(5):1172.

Publications