NeuroMab™ Mouse Anti-Human Amyloid Beta 1-15 Monoclonal Antibody (CBP2496)

Product Overview

Description

Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor protein (APP) through sequential proteolytic cleavage of APP by β- and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

Immunogen

Dityrosine cross-linked human Aβ1-40.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2496

Applications

IHC-F; ELISA; IHC-P

Application Notes

IHC-F (1.0- 5.0 µg/mL); ELISA (0.01- 1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1826

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.10% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Amyloid Beta 1-15

Official Name

Amyloid Beta

Full Name

Amyloid Beta

Alternative Names

APP; Aβ; Abeta; Amyloid β

Gene ID

351 (Human); 11820 (Mouse)

Uniprot ID

P05067 (Human); P12023 (Mouse)

References

1. Puig KL, et al. 2012. Exp Gerontol. 48(7): 608.
2. Selkoe DJ, et al. 2016. EMBO Mol Med. 8(6):595.
3. Walsh DM, et a. 2007. J Neurochem. 101(5):1172.

Publications